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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Treatment-resistant depression ： ウィキペディア英語版 Treatment-resistant depression Treatment-resistant depression (TRD) or treatment-refractory depression is a term used in clinical psychiatry to describe cases of major depressive disorder (MDD) that do not respond adequately to appropriate courses of at least two antidepressants. The term was first coined with the development of the concept in 1974. Inadequate response has traditionally been defined as no response whatsoever. However, many clinicians consider a response inadequate if the patient does not achieve full remission of symptoms.〔Papakostas, G. I., & Fava, M. (2010). Pharmacotherapy for depression and treatment-resistant depression. Hackensack, NJ: World Scientific.〕 Cases of treatment-resistant depression in which the course of treatment was not adequate are sometimes referred to as pseudoresistant.〔Souery, D., Papakostas, G., & Trivedi, M. (2006). Treatment-resistant depression. Journal of Clinical Psychiatry, 67, 16-22.〕 Some factors that contribute to inadequate treatment are: early discontinuation of treatment, insufficient dosage of medication, patient noncompliance, misdiagnosis, and concurrent psychiatric disorders.〔 Cases of treatment-resistant depression may also be referred to by which medications they are resistant to (i.e.: SSRI-resistant).〔Berman, R., Narasimhan, M., & Charney, D. (1997). Treatment-refractory depression: definitions and characteristics. Depression and Anxiety, 5, 154-164.〕 == Prevalence == Treatment-resistance is relatively common in cases of MDD. Rates of total remission following antidepressant treatment are only 50.4%. In cases of depression treated by a primary-care physician, 32% of patients partially responded to treatment and 45% did not respond at all.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Treatment-resistant depression」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.